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The DRB2, DRB6, DRB7, DRB8 and DRB9 are pseudogenes. In immunology, antigens (Ag) are structures (aka substances) specifically bound by antibodies (Ab) or a cell surface version of Ab ~ B cell antigen receptor (BCR). In 2016, there were 216,108 new cases of leprosy registered, corresponding to a global detection rate of 0.29 per 10,000 people. In 2015, 94% of the new leprosy cases were confined to 14 countries. This leads to eventual activation of PKCβ from the calcium and DAG. PKCβ phosphorylates (either directly or indirectly) the NF-κB signaling complex protein Carma1 (the complex itself comprising Carma1, BCL10, and MALT1). Hypersensitivity reactions may be immune mediated and non- immune mediated [7], even though a few authors use the term hypersensitivity reaction synonymously with drug allergy. Publisher: Jaypee Brothers Medical Publishers Private Limited; 4 edition (2015)
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